In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of “ex-differentiation” in which cells begin to lose their identity, and how all of this makes up the “Information Theory of Aging”, and the difference between “biological age” and “chronological age” and how we can measure biological age through DNA methylation clocks.
Can we really cure aging? David Sinclair thinks so, and he’s going to try to prove it. David Sinclair is a scientist and entrepreneur working on increasing human health, productivity, and lifespan. His research is aimed at understanding why we grow old and using this knowledge to prevent and treat both rare and common diseases. He is perhaps best known for identifying resveratrol from red wine as an anti-aging molecule. He has founded four biotechnology companies; to treat age-related diseases.
Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters (these being NR, NMN, NAD IV drips and shots), resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.
Rich Roll presents a masterclass on healthy aging, breaking down the latest research and wisdom shared by past guests & experts in the field of longevity science.
Harvard professor David Sinclair believes that not only can we slow aging down, but we can also actually reverse it. In this episode of Health Theory with Tom Bilyeu, David Sinclair explains the three levels of aging, and what can be done on each level. He describes the lifestyle changes that slow aging down, the drug treatments that begin to stop aging, and experimental new procedures that may actually reverse aging once they are fully developed.
The panel of anti-aging and longevity experts discussed major aging breakthroughs, the disease of aging, and tips to live longer.