David Sinclair Supplements List: Complete Longevity Guide

Each supplement has its own purpose and benefits, and in this section you will learn everything you need to know about David Sinclair’s supplements.

1. Nicotinamide Mononucleotide (NMN)

Nicotinamide Mononucleotide (NMN) supplements are central to David Sinclair’s anti-aging strategy. They are designed to boost NAD+ levels, a molecule critical for cellular energy production and DNA repair, which declines with age.

Simply put, NAD+ is the battery that powers our cells and NMN works as a precursor to NAD+, helping your body produce more of it naturally.

• Dosage: 1 gram daily in the morning.
• Purpose: Serves as a precursor to NAD+, essential for cellular energy and DNA repair.
• Scientific insights: Studies indicate NMN can enhance NAD+ levels, potentially mitigating age-related decline and, supposedly, extending healthspan.

2. Resveratrol

David Sinclair’s resveratrol is a plant compound, often found in grapes and red wine, that plays a unique role in longevity. It activates sirtuins – proteins that are responsible for cellular health and repair.

Resveratol is often paired with NMN because together, they work as a team. NMN raises NAD+, which powers up sirtuins, and resveratrol activates them.

• Dosage: 1 gram daily, taken with yogurt to improve absorption.
• Purpose: Activates sirtuins, proteins linked to longevity.
• Scientific insights: Research suggests resveratrol may mimic caloric restriction benefits, promoting healthspan.

3. Metformin

Metformin was originally a diabetes medication that has gained attention for its potential anti-aging properties. It works by improving how your body uses insulin, helping regulate blood sugar levels.

However, scientists noticed something surprising – people on metformin often had lower rates of age-related diseases like cancer and heart disease.

• Dosage: 800 mg daily, taken in the evening.
• Purpose: Originally a diabetes medication, now believed to have life-extending properties.
• Scientific insights: Some studies associate metformin with reduced incidence of age-related diseases.

4. Vitamin D3

Vitamin D3 is essential for bone health, immune function, and overall well-being. It’s especially useful for people who live in regions with limited sunlight. Supplementing fills that gap.

• Dosage: At least 2,000 IU daily.
• Purpose: Vitamin D3 supports bone health and immune function.
• Scientific insights: Adequate vitamin D levels are linked to lower risks of osteoporosis and certain cancers.

5. Vitamin K2

Vitamin K2 is often paired with vitamin D3 and helps regulate calcium absorption in the body to prevent artery calcification. It makes sure there is no calcium buildup in blood vessels, which otherwise could lead to heart disease. Vitamin K2 also has a slight blood thinning effect, which may be beneficial (or detrimental, if you already use blood thinning medication). 

• Dosage: Vitamin K2 should be taken in 0.1 mg (100 mcg) daily doses along with vitamin D3.
• Purpose: Vitamin K2 directs calcium to bones and away from arteries.
• Scientific insights: May reduce arterial calcification and improve cardiovascular health.

6. Spermidine

Have you ever heard of autophagy? It’s a fancy word for your body’s natural clean-up process – removing damaged or dysfunctional cells to make room for healthier ones. 

Spermidine, a natural compound found in foods like wheat and soybeans, kickstarts this process and helps declutter your body on a cellular level. Improving autophagy has a multitude of benefits, mostly in the realm of reducing risk of disease and healthspan extension.

• Dosage: 1 mg daily.
• Purpose: Induces autophagy, the body’s cellular renewal process.
• Scientific insights: Animal studies show spermidine can extend healthspan by promoting cellular cleanup.

7. Fisetin

Fisetin is a plant compound found in strawberries, apples, and cucumbers, but you’d need to eat an awful lot of fruit to get required doses. It’s a senolytic, which means it clears out senescent cells.

These are damaged cells that no longer function properly but stick around, causing inflammation and speeding up aging.

• Dosage: 500 mg daily.
• Purpose: Acts as a senolytic, clearing out dysfunctional cells.
• Scientific insights: Research indicates fisetin may reduce senescent cell burden, potentially delaying aging.

8. Quercetin

Quercetin is another senolytic agent with anti-inflammatory effects, often paired with fisetin for an even greater impact. Mostly found in apples, onions, and green tea, it also helps clear out aging cells along with strong anti-inflammatory benefits.

• Dosage: 500 mg daily.
• Purpose: Another senolytic agent with anti-inflammatory properties.

Scientific insights: Studies suggest quercetin can help eliminate senescent cells and reduce inflammation.

9. Trimethylglycine (TMG)

TMG, sometimes called betaine, is a small but powerful molecule that supports methylation. Not sure what that is? 

Simply put, it’s a process that helps your body with DNA repair, energy metabolism, and regulating important functions like brain activity and heart health. 

It’s often paired with NMN to support healthy NAD+ levels and cellular health as NMN uses methyl groups for conversion processes. Supplementing with TMG can help maintain normal methyl group levels.

• Dosage: 500 mg to 1,000 mg daily.
• Purpose: Supports methylation processes, especially when taking NAD+ precursors.
• Scientific insights: Helps maintain homocysteine levels, promoting cardiovascular health.

10. Omega-3 Fatty Acids

Omega-3 are essential fats that your body needs but can’t produce on its own. They’re mostly found in fatty fish like salmon or in supplement form such as fish oil.

They’re important since Omega-3s are key for heart health, brain function, and fighting inflammation.

• Dosage: Standard daily supplementation as directed by the supplement manufacturer.
• Purpose: Supports heart and brain health.
• Scientific insights: Omega-3s are associated with reduced inflammation and lower risk of heart disease.

11. Coenzyme Q10 (CoQ10)

Ever feel like your energy levels just aren’t what they used to be? That might be because of your mitochondria that are responsible for producing energy.

Coenzyme Q10, or CoQ10, plays a key role in keeping these energy generators running efficiently. CoQ10 supplementation is also linked to various heart health benefits.

• Dosage: Standard daily supplementation.
• Purpose: Coenzyme Q10 aids mitochondrial function and energy production.
• Scientific insights: CoQ10 levels decline with age; supplementation may improve energy metabolism.

12. Alpha Lipoic Acid (ALA)

Alpha Lipoic Acid (ALA) is a powerful antioxidant with a unique benefit: it works in both water and fat environments. It makes ALA incredibly effective at fighting oxidative stress throughout your body.

On top of that, it helps regenerate other antioxidants like vitamins C and E, giving your body a second layer of defence.

• Dosage: 300 mg daily.
• Purpose: Acts as a potent antioxidant.
• Scientific insights: ALA may regenerate other antioxidants and support metabolic health.

13. Low-Dose Aspirin

Low-dose aspirin has been around for a long time, but its benefits go far beyond pain relief. 

In small amounts, aspirin can act as an anti-inflammatory and a blood thinner, making it a simple yet effective tool for heart health.

• Dosage: 81 mg daily.
• Purpose: Reduces inflammation and blood clot risk.
• Scientific insights: Low-dose aspirin is linked to lower risks of heart attacks and certain cancers.

14. Statins

Statins are commonly prescribed to manage cholesterol levels. High cholesterol levels can lead to clogged arteries and increased heart disease.

Statins help by reducing the bad cholesterol (LDL) and lowering inflammation in the arteries.

• Dosage: As prescribed.
• Purpose:  Lowers cholesterol levels.
• Scientific insights: Statins reduce cardiovascular disease risk by managing lipid profiles.

15. Taurine

Taurine is an amino acid with a wide range of benefits for your body. It’s especially important for your nervous system, heart, and muscles.

It acts as an antioxidant, helping reduce inflammation and oxidative stress, which are key drivers of aging.

• Dosage: 2 grams daily.
• Purpose: Supports cardiovascular and neurological function.
• Scientific insights: Taurine has been shown to have antioxidant and anti-inflammatory effects.