NMN supplements typically show noticeable effects, such as increased energy and focus, within a few days to weeks, while long-term benefits like improved metabolism and anti-aging effects may take months.
Top 5 NAD+ Supplements to Boost Energy and Vitality
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Kay Takeaways
- NAD+ supplements include a range of health benefits — from increased energy levels, reduced metabolism, and cognitive decline to supporting healthy aging in general.
- Nicotinamide Riboside (NR), Nicotinamide Mononucleotide (NMN), Resveratrol, Trimethylglycine (TMG), and Quercetin are the top 5 NAD+ supplements.
- Be sure to check the purity and form of your NAD+ supplements to get the best value and the most efficiency.
Humans have always wanted to slow down the aging process, and with NAD (Nicotinamide Adenine Dinucleotide) supplements, we might finally get a fighting chance. Clinical trials show NAD supplements have a positive effect on cognitive decline, cellular energy metabolism, DNA repair, and many other benefits.
While it is clear that the NAD+ increase boosts energy levels and helps us age gracefully, you might want to target specific NAD benefits for the most effect. Once you know the overall benefits and the best options, choosing the best NAD supplement for your needs won’t seem that difficult.
Benefits of NAD+ Supplements
As the name suggests, NAD+ dietary supplements are a group of compounds designed to boost NAD+ levels in our cells when taken daily. NAD is a coenzyme crucial in helping proteins and other enzymes, such as sirtuins, to produce energy for various cellular processes.
It’s been found that the decrease of NAD+ in our cells causes many of the unwanted processes in our bodies as we age (1). A healthy diet and some vitamins, especially B3 (nicotinic acid), can help us to gain some of it back. Studies show that creating an abundance of NAD+ with dietary supplements has a profound impact on physiological function as we age (2).
The theory seems straightforward – supplements like NR or NMN replenish NAD+ levels and increase their availability for use in cellular processes. This doesn’t say much until we put it into a broader context of healthy aging.
- Boosting energy levels. Since NAD+ is essential for cells to turn nutrients into energy, cells gain a more effective metabolism for creating the energy needed to survive. As such, NAD+ supplements increase the general energy levels you have during the day and may even be used to treat certain metabolic disorders (3).
- Supporting aging and longevity. Besides the correlations of NAD+ decline and age, there are also various cellular functions that are positively impacted by NAD boost. Heightened metabolism reduces the chances of neurodegenerative disorders, such as Alzheimer’s and improved cellular repair helps to fight old age skin issues (4).
- Improving brain health and mental clarity. The brain is the most energy-demanding organ, so boosting cell energy production with NAD supplements improves its functioning. While more research is needed for testing humans on mental performance tasks, the mechanisms of how and levels help avoid mental decline and improve overall brain health are clear (5).
- Enhancing energy metabolism and DNA repair. An increase in NAD+ levels improves mitochondrial function, which is crucial not only for cellular energy production but also for cell repair. The cells are more effective at activating various DNA repair mechanisms and other enzymes involved in this process. This is vital for sustaining energy levels and preventing age-related genetic diseases as we grow older (6).
- Supporting healthy aging and combating fatigue. Supporting healthy aging and combating fatigue. Due to the decrease in energy levels and cellular repair capabilities, at least partially caused by NAD+ decline, many people in old age start to experience fatigue. Boosting your NAD+ levels mitigates such diseases since metabolic function, aerobic capacity, cell repair, and other functions are improved (7).
Studies suggest that more research is needed to uncover the efficiency of NAD supplements for the general public. You can still expect the general health effects with a healthy diet, physical exercise, and the right choice of NAD supplements.
How to Choose the Right NAD+ Supplement for You
There are several factors to consider when choosing the best NAD+ supplements, the most important of which are the purity of the ingredients and the dosage form available. It’s up to you to decide, but there are some general guidelines that healthcare providers recommend.
Purity and Third-Party Certifications
Some less reputable brands often include additives other than the needed NAD+ supplements to lower the costs. Impure supplements might be less effective or, in extreme cases, even cause unwanted side effects. It might also lead to unequal intake, so you want to make sure that the supplement consists of only the active substance you need.
A very small margin of error is unavoidable, but it should be up to a minimum. It would be too big of a hassle to test the NAD+ supplements yourself. The best way is to rely on third-party certifications from reputable institutions.
PartiQlar supplements are proven to be 99% pure as tested by HPLC, LC-MS, LC-MSMS, 1HNMR, and 13CNMR methods. Our supplements have been tested by the National Sanitation Foundation and Underwriters Laboratories. Our offerings have even been awarded for Good Manufacturing Practice (GMP) compliance.
Form and Price
It’s also important to choose the correct form of NAD+ supplement for the best price you can get. Different brands focus on different forms of supplements. The most common ones are powders, sublingual liquids, and capsules.
Powder supplements are best for creating customizable doses but might include some inaccuracies when dosing. Sublingual liquids are known for being efficiently absorbed into the body, but this form of intake is the least studied, might induce side effects, and costs the most.
PartiQlar offers NAD+ affordable capsule form NAD+ supplements in carefully dosed forms. You can trust that each capsule is of the same size, usually with a minimum dose of 500mg, but it might vary depending on the supplement you choose.
Top 5 NAD+ Supplements Ranked
#1 Best NAD+ Supplement Overall – Nicotinamide Riboside (NR)
Nicotinamide riboside (NR) is a form of vitamin B3 serving as a direct precursor to NAD+. This enzyme is involved in various cellular processes, such as fighting metabolic disorders, cognitive decline and increasing physical performance through increasing aerobic capacity.
Some studies suggest that NR is superior to NMN and other NAD+ supplements for increasing NAD+ levels since it enters cells more easily (8). More research is still needed to settle the debate, but it’s already clear that NR supplements can only strengthen NMN, and they don’t counter each other.
#2 Best for Energy Increase – Nicotinamide Mononucleotide (NMN)
NMN (Nicotinamide Mononucleotide) is a naturally occurring molecule with anti-aging and longevity properties proved by clinical trials. Our bodies use NMN to produce NAD+ and transport it using specialized proteins to improve DNA repair, aerobic capacity, cell and brain health, as well as many other benefits.
One of the most noticeable effects of NMN is the improvement of cell metabolism, which even shows itself as a short-term burst of energy (9). That’s why it’s often recommended to take NMN supplements, as well as other NAD+ compounds, early in the morning to boost your energy levels before the day.
#3 Best for Heart Function – Resveratrol
Resveratrol is a natural compound known for activating sirtuins. It’s found in certain grapes and, to a small capacity, even red wine. Activating these sirtuin enzymes is impossible without enough NAD+, but resveratrol kickstarts the process. That’s why supplementing resveratrol is crucial for getting the most potential benefits out of your NAD+ boost.
Resveratrol supplement users often report feeling cognitive improvements and even weight loss. Long-term effects of Resveratrol may have various anti-aging effects as well as improve your cardiovascular health. The latter is so noticeable due to improved endothelial function, which supports blood flow and might even lower blood pressure (10).
#4 Best for Physical Endurance – Trimethylglycine (TMG)
Trimethylglycine (or TMG for short) is an amino acid glycine with three methyl groups attached to it, which allows it to act as a methyl donor. Methyl is a building block of chemical reactions in the body. Our bodies synthesize TMG itself from common foods we eat, such as bread, but it might be enough when NAD+ levels are supplemented.
It’s recommended for a supplement plan that boosts NAD+ levels to include enough methyl groups as they are used up in NAD pathways (11). TMG supplements have the most noticeable effect on enhancing physical performance as cells become better equipped to continue various cellular processes under physical stress.
#5 Best for Brain Health - Quercetin
Quercetin is a type of flavonoid, a protective compound found in plants. It has been shown to improve blood flow to the brain, promote the growth of new neurons, and reduce cognitive decline overall. Although it is not an NAD+ supplement itself, it interacts with NAD+ pathways, synergizing with positive effects on the brain.
Taking Quercetin supplements is likely to improve cardiovascular health and the immune system, even helping with seasonal allergies. Long-term use of Quercetin activates pathways like AMPK that reduce neuroinflammation (12), which is one of the reasons it’s useful for transforming NAD+ increase to benefits for brain health.
Frequently Asked Questions
What age does NAD decline?
It’s known that NAD+ levels decline as we grow older. The most noticeable drop is around the age of thirty (13). Some of the NAD+ declines can be compensated with certain foods and vitamins, but NAD+ supplements are the most efficient.
Are NAD+ injections better than pills?
NAD+ injections are uncommon in ordinary supplementation and can only be performed with the oversight of a healthcare provider. When done safely, they might have some potential benefits over capsules or other NAD+ forms. Studies are still conducted on the long-term safety of injections, so capsules seem as a safer option to boost NAD+ levels.
Does alcohol affect NAD+ levels?
Wine might contain small amounts of resveratrol, as it is naturally found in the skin of certain grapes. However, the potential increase in NAD+ levels is negligible compared to the adverse effects alcohol may cause. Alcohol consumption has been shown to reduce NAD+ levels, disrupt various metabolic processes, and damage the liver (14).
Is NAD just vitamin B3?
No. Unfortunately, it’s a common misconception about NAD+ and its supplements. Most probably. It arises from the fact that NAD+ is synthesized from vitamin B3 derivatives, such as nicotinic acid (niacin) and nicotinamide riboside (NR). Vitamin B3 is one of the precursors to NAD+, but it’s a different compound.
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Resveratrol, a powerful phytochemical found in foods like red grapes and dark chocolate, supports heart health and longevity, with its benefits amplified when combined with NMN to boost NAD+ levels in the heart and muscles.
This blog post discusses the FDA's recent decision to no longer classify NMN as a dietary supplement, examining the implications for its availability and safety in the market.
When you combine NAD and resveratrol, a bunch of things happen that benefit your body. Resveratrol activates SIRT1, which is a gene that tells your body to make more NAD+. And more NAD+ means your cells work harder, better, and in-line with your anti-aging goals.
Together, they can help with:
- Energy metabolism. You may feel more energetic throughout the day as your cells will be able to produce more energy and do it more efficiently.
- Cellular repair. Higher NAD+ levels help your body fix damaged cells, potentially slowing down aging.
Muscle recovery. If you’re trying to stay active as you age, the combination of NAD+ and resveratrol could help your muscles recover faster and work better.
