Unlocking the Power of Calcium Alpha-Ketoglutarate

Here are the top ca-akg supplement benefits, but this is non-exhaustive. We believe that its range of potential benefits is still understudied, and new possibilities may be explored in the future.

•  Longevity and Healthy Aging

The main attraction of Ca-AKG for many users is its potential impact on longevity. Studies have shown that ca AKG may support cellular health, reduce inflammation, and even slow biological aging. In fact, one prominent study indicated that AKG supplementation in mice helped reduce their biological age, suggesting it could have similar benefits for humans.

So, does AKG reverse aging? While ca AKG may not completely reverse aging, it can play a significant role in healthy aging by supporting cellular repair and minimizing age-related damage. In a landmark mouse study published in 2020 in Cell Metabolism¹, journal, calcium AKG supplement administration revealed a significant extension of the lifespan of mice, increasing survival, compressing morbidity, and reducing frailty in mice.

A separate study on a commercial product with Ca-AKG + vitamins combination’s effect ² on human biological aging was also tested in 42 healthy individuals in a span of 4 to 10 months. According to the TruAge DNA methylation test, the participants showed an average 8-year reduction in biological aging after 7 months of use. 

A 2023 clinical trial³ is also currently investigating a 6-month 1g treatment of Ca-AKG in 120 middle-aged (40-60 y/o) adults; however, results are still pending, but it is worthwhile to keep an eye on this one once the findings are out by early 2025

• Potential for Grey Hair Improvement

Although grey hair is often seen as a natural part of aging, ca-AKG’s effects on cellular energy and oxidative stress may also benefit hair pigmentation. By supporting cellular health in hair follicles, Ca-AKG could help maintain natural hair color longer, potentially slowing down the appearance of grey hair.

If you are wondering, “What are the potential benefits of Ca-AKG for grey hair?”, let’s look at the research findings. While more studies are needed, especially human trials, Ca-AKG’s cellular support might contribute to healthier, more vibrant hair. In fact, as found in the Cell Metabolism mice study ⁴ the researchers found that ca-AKG could reverse the age-dependent hair-graying in the first cohort of mice, while in the second cohort, it could prominently prevent hair-graying of female mice.

• Muscle Recovery and Performance

If you’re into fitness, Ca-AKG could also help you by supporting your athletic performance and muscle recovery. Its role in cellular energy production can reduce muscle fatigue and promote faster recovery times post-exercise. Ca-AKG can also increase your muscle protein synthesis, muscle endurance, and skeletal muscle blood flow.

AKG can also inhibit prolyl hydroxylase, an enzyme involved in muscle protein breakdown, which is consistent in studies showing that prolyl hydroxylase reduction enhances skeletal tissue regeneration⁵. Hence, ca AKG is often favored among athletes looking for a natural way to enhance energy, endurance, and resilience.

•  Cognitive Benefits

Ca-AKG doesn’t just benefit the body—it may also support the brain. A 2022 review of AKG supplementation for human health⁶ improvement highlights the importance of AKG in potentiation, memory, and neurotransmission. During ischemia, alpha-ketoglutarate is critical in brain homeostasis by maintaining the viability of brain cells⁷. Furthermore, calcium AKG can fight off oxidative stress, a risk factor or neurological disorders like Alzheimer’s and Parkinson’s, hence providing a basis for its protection against cognitive decline and promoting brain health.

Although there’s currently no human clinical trial Ca-AKG providing solid evidence of its effects on brain function, a 2006 study of an ornithine form of AKG⁷ shows that it can significantly enhance awareness and diminish neurological damage when administered within 96 hours of stroke onset