Alpha GPC vs Citicoline: Which Nootropic Is Better?
Key takeaways:Â
- Both Alpha GPC and citicoline can improve brain function and prevent cognitive decline, especially if used together.
- Due to its high bioavailability and being more easily absorbable for the brain, Alpha GPC stands out as a superior product.
- Alpha GPC provides a faster cognitive impact, while citicoline might have weaker but longer-lasting benefits.
If you are on the lookout for additions to your dietary supplements to improve your cognitive performance, Alpha GPC and citicoline are two nootropics to pay your attention to.
They let you prevent cognitive impairment or optimize your learning capabilities and develop a sharper mind. But to secure these benefits with the best choice, you must know the difference between citicoline and Alpha GPC.
In this article you will find the comparison of the main features and cognitive benefits of these supplements that might be useful in determining the best choice for you.
What Is Alpha GPC?
L-Alpha Glycerylphosphorylcholine (Alpha GPC) is a choline-containing compound that is crucial for the acetylcholine synthesis in the body.
Acetylcholine is a vital neurotransmitter involved in learning, memory, and muscle contractions, making it a necessary component in both physical and mental performance.
Alpha GPC can be distinguished for its efficiency in crossing the blood-brain barrier. It is one of the most bioavailable supplements of choline, which means that it can be absorbed in the brain for systemic circulation.
Benefits of Alpha GPC:
- Improves brain function and memory (1).
- Supports neurotransmitter synthesis, particularly acetylcholine (2).
- Boosts learning and mental processing speed (2).
- Helps in physical performance and muscle strength (3).
- Might work as a preventive means to cognitive decline and neurodegenerative diseases like Alzheimer’s disease (4).
Common uses of Alpha GPC:
- Cognitive enhancement for students and professionals.
- Support for neurodegenerative conditions.
- Performance boost for athletes due to its effects on growth hormone secretion.
- Alternative to choline bitartrate for individuals seeking higher bioavailability.
What Is Citicoline?
Citicoline, also known as CDP-Choline (Cytidine 5′-diphosphocholine), is a precursor to phosphatidylcholine and aids in cell membrane repair and maintenance.
It stimulates neurotransmitter synthesis which is important for cognitive performance. Boosted levels of dopamine and acetylcholine lead to improved cognitive performance.
Benefits of citicoline
- Supports brain energy production by increasing adenosine triphosphate (ATP) levels (5).
- Enhances focus, memory, and attention span (6).
- Aids in the repair of neuronal function (7).
- May help slow age-related cognitive impairment (8).
Neuroprotection and stroke recovery are two reasons for which citicoline is often used. Since it improves brain function, users can enjoy higher mental clarity and top levels of concentration when challenging tasks need to be done.
While citicoline may not be as strong as Alpha GPC for immediate cognitive enhancement, it works well with other nootropics in dietary supplements for combined impact on the brain.
Alpha GPC vs Citicoline - Key Differences
To compare these supplements, we need to look through separate categories on which they work.
Alpha GPC increases acetylcholine synthesis and crosses the blood-brain barrier effectively. It means high bioavailability with rapid absorption that makes the supplement work immediately.
Citicoline, on the other hand, can be noted for slightly slower absorption. However, it has longer-lasting effects since citicoline helps with neurotransmitter production.
Alpha GPC has higher choline content that gives more power in supporting acetylcholine production, while citicoline is helpful in phospholipid metabolism despite the fact that it has a rather moderate choline content.
If you need strong memory and learning enhancement, Alpha GPC is a preferable choice, whereas citicoline helps with better focus and sustained mental energy because it increases dopamine (9) and acetylcholine levels (10).
Citicoline is a well-tolerated supplement. However, it can cause mild digestive issues. Alpha GPC can also have some negative side effects, such as headaches, low blood pressure, or nausea, if taken in high doses.
Even though Alpha GPC may slow cognitive decline and neurodegeneration, it is more popular among athletes due to muscle recovery benefits. Citicoline is known for its neuroprotection and, therefore, is often preferred for long-term cognitive support.
Who Should (or Shouldn’t) Take Alpha GPC & Citicoline?
Using these supplements together might have a fast-acting and long-term cognitive impact. Nevertheless, you should not exceed the limits of safe doses if you want to avoid potentially negative side effects for overall well-being.
However, each of these compounds has its own benefits that might lure you to use one rather than the other.
Who benefits most from Alpha GPC?
- Those seeking fast-acting cognitive enhancement.
- Athletes looking for physical and mental performance boosts.
- Individuals concerned with cognitive decline prevention.
Who benefits most from citicoline?
- People who need long-term neuroprotection.
- Individuals looking to support cell membranes and brain repair.
- Those who prefer a milder, sustained cognitive boost.
Who should avoid these supplements?
- Pregnant or breastfeeding women should consult a doctor first.
- Those with low blood pressure.
- People who are sensitive to choline-related side effects like headaches or nausea.
Why Choose Alpha GPC Over Citicoline?
If you are in doubt when choosing between citicoline and Alpha GPC, the following benefits might give you a glimpse of why the latter is a superior product:
- Due to its direct role in synthesizing acetylcholine, Alpha GPC has a stronger impact on brain function.
- Alpha GPC is ideal for athletes and those needing a mental or physical energy boost since it provides both.
- For more efficient choline delivery, this supplement allows an efficient absorption in the brain due to its high bioavailability and blood-brain crossing abilities that give it an advantage over similar alternatives.
For the best cognitive supplement, try partiQlar’s Pure Alpha GPC – a high-quality, lab-tested formula designed for optimal absorption and cognitive performance.
Conclusion
Both citicoline and Alpha GPC offer cognitive benefits, but the latter stands out for its rapid effects and higher choline concentration. Whether you need an immediate mental edge or long-term brain support, understanding their differences can help you make the best choice.
FAQ
Is it OK to take Alpha GPC every day?
Daily dosages are acceptable and healthy, as long as you break your intakes into cycles because over time your body will become more tolerant towards this supplement, thus reducing its efficiency.
Is citicoline a stimulant?
Citicoline is not considered a stimulant. Although it may slightly boost your mental energy, it will not affect your mental state.
What are the symptoms of choline deficiency?
Brain fog, memory issues, fatigue, and muscle weakness.
Does citicoline increase acetylcholine?
Yes, but it also supports dopamine and brain cell repair.
Should I take choline or citicoline?
Citicoline is more effective than choline bitartrate alone for cognitive support.