NMN supplements typically show noticeable effects, such as increased energy and focus, within a few days to weeks, while long-term benefits like improved metabolism and anti-aging effects may take months.
How NMN and Resveratrol Boost Health and Longevity
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The effects of NMN and Resveratrol supplement each other. NMN (nicotinamide mononucleotide) fuels the production of NAD, a coenzyme crucial for cell metabolism, while resveratrol helps boost sirtuin production, a NAD-dependant protein family crucial for cellular repair.
Taking NMN + resveratrol together was popularized by Dr. David Sinclair, a well-respected human longevity and epigenetics researcher. Many studies are still ongoing, but do you need to wait before taking the NMN resveratrol combo? The combined effects of healthy aging and potential longevity increase are already known.
What is NMN?
NMN (Nicotinamide Mononucleotide) is a precursor for a coenzyme called NAD (Nicotinamide Adenine Dinucleotide). It helps other enzymes and proteins to support energy production for our cells to function. It’s naturally found in some foods, such as milk, fish, and green vegetables, rich in Vitamin B3.
We cannot take enough NAD directly, since you would need to eat extremely large amounts of foods as NAD by itself struggles to pass through cell membranes. That’s why NMN supplementation is the next best thing for cellular health.
NMN uses specialized transporter proteins (Slc12a8) and other precursors to pass into the cells (1). It’s the reason why NMN supplementation is so effective in improving cell metabolism, DNA repair function and a number of other issues linked with old age.
It’s known that NAD levels start to decline around thirty (2), which disrupts healthy aging of our bodies. Thus, NMN supplementation can be confidently linked with reducing negative aging effects of fatigue, brain fog, lack of energy, risk of diabetes, and many others.
What is Resveratrol?
Resveratrol is a molecule belonging to a family called polyphenols that protects plants from injury or infection. We already consume some of it from foods like grapes, red wine, peanuts, and others. It comes in two molecular forms – cis- and trans-.
Trans-resveratrol is more bioactive and, thus, a more absorbable form of resveratrol used in supplements. The same properties that help plants fight oxidative stress are likely to be beneficial for antioxidant and anti-inflammatory properties of cells in animals and humans (3).
Trans-resveratrol helps to fight type 2 diabetes, improves cardiovascular and metabolic function, and helps against diseases like Alzheimers. Most of these cellular health benefits seem to be linked to sirtuin activation by regulating specific molecular pathways (4).
Sirtuins are a family of seven proteins that play a crucial role in cellular health, such as fighting inflammation and oxidative stress and increasing cell metabolism. All these processes induced by trans-resveratrol are crucial for healthy aging and longevity.
How NMN and Resveratrol Work Together
Many of the benefits of nicotinamide mononucleotide (NMN) are also linked to the production of sirtuins since they are NAD-dependent. Simply put, it means that cells cannot produce sirtuins without NAD. This way, trans-resveratrol and NMN supplementation work together to improve cell energy production and, as a result, benefit cellular health and healthy aging.
NMN helps fuel our cells with NAD, part of which is then used for sirtuin production, while trans-resveratrol increases its activation rate. On their own, both supplements are less effective, but in combination, they boost each other’s effects.
While nicotinamide mononucleotide (NMN) is beneficial on its own, without trans-resveratrol, less of the NAD produced will be used for sirtuin activation. Similarly, trans-resveratrol on its own will activate fewer sirtuins since the cells might lack NAD without boosting the production with NMN supplementation.
Such reasoning is backed by scientific studies as well. The framework on how the trans-resveratrol and NMN interact with each other is still debated. Yet, it’s already agreed that trans-resveratrol enhances the efficacy of NMN supplementation while providing benefits of their own (5).
One study conducted a randomized clinical trial on older adults using both trans-resveratrol and NMN supplementation (6), suggesting that they could help with complications and risk of diseases like type 2 diabetes. Unfortunately, there is a lack of clinical trials on humans comparing the effects of each compound together.
There are no side effects of taking nicotinamide mononucleotide (NMN) besides a slight stomach distress (7). Trans-resveratrol in high doses can cause gastrointestinal distress and have negative effects together with certain drugs (8).
Safety is anecdotally proved by the users of NMN and resveratrol, such as Dr. David Sinclair himself. In various podcasts and interviews, he has claimed to take both trans-resveratrol and NMN supplements in moderate doses without many negative side effects but with benefits to healthy aging.
Health Benefits of NMN and Resveratrol
NMN resveratrol combination strengthens each other’s functioning through the production and usage of NAD for cell energy production. To some extent, you can expect many of the same benefits while taking nicotinamide mononucleotide (NMN) or trans-resveratrol alone, but together they amplify the same effects on cellular health.
Anti-Aging and Longevity
Studies have proven that trans-resveratrol increases the longevity of many species, such as yeast, worms, fish (9), and mice (10). Clinical trials are yet to prove the longevity effects of trans-resveratrol for humans. However, its effects on sirtuins give strong reason to think that it will be effective.
Trans-resveratrol activates the SIRT1 sirtuin and increases its responsiveness to NAD, which is known as the “protein of longevity” (11). Via the boost in the production of NAD, NMN also improves healthy aging. It’s not just because of the correlation between the decline of NAD and old age.
Studies on mice showed that NMN supplementation increases insulin sensitivity (12), DNA repair (13), and increases their lifespan (14). It is safe to assume that the NMN + resveratrol combination will be more effective in all of these anti-aging effects.
Metabolic Health
A study on rhesus monkeys has shown that trans-resveratrol can counteract a bad diet to some extent (15). In large part this is due to cell energy production boost that increases the overall metabolism of the body.
Both trans-resveratrol and NMN have the best results for patients with type 2 diabetes and similar conditions related to slow metabolism. NMN improves the metabolic pathways for sirtuins (16), while trans-resveratrol activates more of them.
Cardiovascular Health
A randomized study of amateur runners showed that moderate to high doses of NMN increased the physical performance of subjects (17). This is largely due to increased oxygen uptake that results in better heart functioning and helps to avoid cardiovascular diseases in the long run.
Meta-analysis studies of the effects of trans-resveratrol on cardiovascular health confirmed that it has a positive effect on blood pressure (18). Bettering the sirtuin activation and cell energy production helps improve glucose control and generally lowers blood pressure for patients who tend to have it higher.
Overall Wellness
All these benefits should already signal that NMN and resveratrol combination boost your overall wellness. More specific studies were done when researching the impact of immune system trans-resveratrol. One of them found that trans-resveratrol activates detoxifying enzymes that can protect cells from deteriorating (19).
By increasing the NAD levels, NMN helps to protect cells from oxidative stress that disrupts their proper functioning (20). Protecting cells in such a way has a wide range of benefits to cognitive function, physical endurance, metabolism, and healthy aging.
Recommended Dosage
Most studies that have used nicotinamide mononucleotide (NMN) or trans-resveratrol have administered low daily doses of these substances. NMN is most frequently taken from 250 mg to 500 mg, while benefits against specific diseases or to physical performance have been noticed in higher doses of up to 1200 mg.
Trans-resveratrol is generally taken in higher doses from 500 mg and might show significant benefits in daily doses of above 2g. However, higher doses might induce a stronger stomach upset. The same can be said about NMN in high doses, so it’s best to take some precautions.
Both supplements are best taken in the morning on an empty stomach. In case of stomach distress, it’s recommended to take the supplements with yogurt or other light food. The best strategy to reap the most benefits is to increase the dose gradually.
Start with a single 500 mg capsule of each NMN and resveratrol. After at least a month, try to increase the doses. In case you don’t feel any benefits or side effects appear, decrease the dosage of each at a time.
NMN resveratrol combination is generally safe for humans, but as with all supplements, precautions should be taken, especially while mixing different substances. It’s important to keep track of your intake and well-being to adjust doses if needed.
Conclusion
Nicotinamide mononucleotide (NMN) and resveratrol work hand in hand to promote healthy aging processes. NMN is excellent in producing NAD, while trans-resveratrol is used to produce sirtuins. Their combination is generally safe, but it’s best to start with moderate doses, which increase gradually.
Frequently Asked Questions
Should you take NMN and Resveratrol together?
NMN- Resveratrol combination increases each of the supplement’s effectiveness. You can take each of them separately for some of the benefits, but many experts, such as Dr. David Sinclair, recommend taking both together for the full effects.
Can NMN and Resveratrol improve energy levels?
Yes, the Nicotinamide Mononucleotide (NMN) + Resveratrol combination is going to boost your cell energy production and, thus, overall energy levels. Even NMN alone gives a short energy boost after intake. Combined with Trans-Resveratrol, NMN is more likely to increase your energy as a long-term effect.
What is the best time of day to take them?
It’s generally recommended to take the NMN + Resveratrol early in the morning on an empty stomach. The supplements will be better absorbed, and the immediate energy boost won’t disturb your sleep. The NMN-Resveratrol combo can also be taken half an hour before a workout.
Are there any side effects of NMN and resveratrol?
PartiQlar’s NAD boosters are 100% suitable for vegans. For supplements from other brands, make sure to check the label to ensure compatibility.
What are the signs that an NAD booster is working?
There are no known major side effects from small doses of NMN-Resveratrol combination or separate usage. In higher doses, NMN and Resveratrol might cause stomach upset. This is especially true for Trans-Resveratrol, which is why it’s recommended with meals containing healthy fats, such as avocados or yogurt for example.
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