TMG is an amino acid that supports heart health, boosts performance, and replenishes methyl groups.
Pure TMG
$11.89
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Benefits
Benefits
- Supports heart health – helps lower homocysteine levels for better cardiovascular function.
- Boosts methylation – replenishes methyl groups vital for DNA repair and detoxification.
- Enhances energy and performance – aids in endurance, strength, and muscle recovery.
Dosage
Dosage
Take one capsule (500 mg) daily with or without food for supported methylation.
You may adjust the dose according to your health goals.
Ingredients
Ingredients
- 500 mg of highly-pure Trimethylglycine (TMG) per capsule.
- Vegetable cellulose capsule (safe for vegans).
Also Bought Together
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"partiQlar prioritizes safety and purity, leading to enhanced user benefits."
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GET TO KNOW
What is a TMG Supplement?
TMG (Trimethylglycine) is a dietary supplement, frequently paired with NMN (Nicotinamide Mononucleotide) to enhance the benefits of increased NAD+ levels while maintaining healthy methylation. TMG acts as a methyl donor, providing essential methyl groups necessary for various physiological processes. While NMN boosts NAD+ levels, which are crucial for energy production, this process can deplete your body’s methyl stores.
By using TMG alongside NMN, you replenish these methyl groups, ensuring that NAD+ production remains efficient and balanced.

Homocysteine Levels
Human studies show that betaine effectively and reliably reduces homocysteine levels in both healthy individuals and those with various conditions. Betaine can directly methylate homocysteine, offering potential cardiovascular health benefits.
Cell Hydration
TMG also functions as an osmolyte, a molecule that moves in and out of cells to regulate their hydration status. Higher intracellular concentrations of TMG enhance cell hydration and resilience to stressors.
Methylation
TMG is a key natural methyl donor that supports methylation, a vital process for energy production, cell repair, and DNA synthesis. By donating its methyl group to convert the toxic metabolite homocysteine into methionine, TMG helps maintain cellular health and function.
Physical Performance
Various studies suggest that TMG may enhance resistance exercise performance, particularly in endurance and high metabolic stress activities. It has shown a potential to improve body composition, increase arm muscle size, boost barbell press capacity, and slightly enhance power (though not strength).

HOW TO USE TMG
Pure TMG Dosage
Daily Dosage Recommendations:
To Accompany NMN Supplementation – Well-known scientists who use a TMG dietary supplement with NMN typically take 500 mg of TMG daily.
For Reducing Homocysteine Levels – for healthy individuals, a Trimethylglycine dosage of 1.5–3 grams per day may be effective in managing homocysteine levels.
Best Practices:
TMG is water-soluble and can be taken on with or without food. If you experience mild discomfort taking it on an empty stomach, consider having a healthy snack.
QUALITY
Pure TMG Supplement Facts
Highest Purity: partiQlar’s Pure TMG is free from unnecessary fillers and additives. Our formulation contains only pure, active ingredients for maximum potency.
Single-Ingredient Formulation: supported by scientific research, Pure TMG provides an effective 500 mg dosage of trimethylglycine (as betaine anhydrous), ensuring optimal flexibility.
Third-Party Tested: each TMG dietary supplement and batch undergoes rigorous third-party testing for purity and potency, ensuring transparency and reliability, providing our customers with the best TMG supplement we can reasonably create.
Sourced from a reputable and certified supplier, it is manufactured in a facility registered with the US FDA and NSF, adhering to stringent regulatory standards for safety and quality assurance.

Frequently Asked Questions About Pure TMG
Seriously, our team of supplement experts and scientists have answers
Why partiQlar’s Pure TMG?
Why partiQlar’s Pure TMG?
PartiQlar’s Pure TMG offers unmatched quality with a high-purity, single-ingredient formulation free from unnecessary fillers and additives. Each capsule provides 500 mg of Trimethylglycine (as betaine anhydrous), ensuring maximum potency and flexibility. It is third-party tested for purity, potency, and safety, guaranteeing you receive the highest quality product.
Can Pure TMG help boost my energy levels or reduce fatigue?
Can Pure TMG help boost my energy levels or reduce fatigue?
Yes, TMG supplementation can help combat fatigue and increase energy by supporting cellular processes and reducing homocysteine levels, which may also aid in maintaining healthy liver function. Benefits of Trimethylglycine also extend to maintaining optimal methylation, which is vital for energy production and reducing fatigue. Pairing TMG with NMN can further enhance energy and metabolic support.
Can TMG be taken alongside other supplements like NMN?
Can TMG be taken alongside other supplements like NMN?
Absolutely! TMG is often paired with NMN to enhance the benefits of increased NAD+ levels while maintaining healthy methylation. While NMN boosts NAD+ levels, TMG supplementation replenishes the methyl groups needed for various physiological processes, ensuring balanced and efficient cellular function.
How to take Pure TMG?
How to take Pure TMG?
If this is your first bottle of Pure TMG, start low – 1 capsule (500 mg) every day should suffice. After taking it for a few weeks, observe for any effects and increase the dose if you don’t feel any. In general, TMG can be taken with or without food, though we recommend swallowing the pill with water for better comfort.
How much Pure TMG should I take?
How much Pure TMG should I take?
For those supplementing with NMN, 500 mg of TMG daily is typically recommended. For managing homocysteine levels, a dose of 1.5–3 grams per day may be effective for healthy individuals. To get the intended TMG supplement benefits, It’s best to start with a lower dose and gradually increase as needed, based on your specific health goals and response.
When is the best time to take TMG supplements?
When is the best time to take TMG supplements?
The most popular timing for TMG intake is the morning. Users generally tend to appreciate the slight boost in energy and alertness TMG provides. However, if you’re upping the dosage, you might want to split the timing. Then the second best time to take TMG is 1-2 capsules in the morning, and 1 in the afternoon.
Is TMG the same as creatine?
Is TMG the same as creatine?
No, TMG and creatine are distinct compounds with different functions. While both are osmolytes, TMG primarily supports methylation, healthy liver function, and heart health, whereas creatine enhances energy production in muscle cells for improved athletic performance.
Are there any side effects associated with TMG?
Are there any side effects associated with TMG?
TMG is generally safe, but some people may experience mild digestive discomfort, such as nausea or bloating. If this occurs, take Pure TMG with a healthy snack or meal. Starting with a lower dose can also help minimize potential side effects. Consult with a healthcare provider if discomfort persists.
What is the best source of TMG?
What is the best source of TMG?
Beets are the richest natural source of TMG. Fun fact – beets in latin are named Beta vulgaris, from which TMG’s alternative name, betaine, originates from. Other good natural sources of TMG are spinach, quinoa, wheat bran and wheat germ, whole grains, and shellfish.
What TMG is best for?
What TMG is best for?
TMG is widely used as a methyl donor, which means that it transfers methyl groups to many important biochemical reactions in your body. This supports methylation, which affects everything from the DNA to your mood.
Who should not take TMG?
Who should not take TMG?
TMG is generally safe for everyone. However, there are some groups of people who might be at an elevated risk. If you’re suffering from bipolar disorder or various similar medical conditions, are prone to overmethylation, take certain medications, or are pregnant and breastfeeding, refrain from TMG or consult a medical professional first.
Can you take TMG every day?
Can you take TMG every day?
Yes, you can and should take TMG every day. As with any supplement, effects may not be instant – they usually can be felt after a few weeks of use. This warrants the need to take this supplement at least once a day. If you’re looking to strike a sufficient dose, observe your body’s reaction to the supplement and do not exceed amounts of 4 grams a day.
Does TMG raise blood pressure?
Does TMG raise blood pressure?
There is no link between TMG and elevated blood pressure. On the contrary, thanks to TMG’s reduction of homocysteine levels, the strain on your cardiovascular and neural systems reduces. This indirectly may contribute to lower blood pressure.
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